Biological Activity
Potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-α and β, resepctively). Selective for PDGFR kinase over a range of related kinases. Inibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.
Technical Data
| M. Wt | 417.5 |
| Formula | C24H27N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 343787-29-1 |
| PubChem ID | 10158940 |
| InChI Key | DEEOXSOLTLIWMG-UHFFFAOYSA-N |
| Smiles | COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.75 | 100 | |
| ethanol | 41.75 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 11.98 mL | 23.95 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896
Keywords: CP 673451, supplier, CP673451, PDGFRβ, beta, inhibitors, inhibits, platelet, derived, growth, factor, receptor, potent, selective, PDGFR, PDGFR, Tocris Bioscience
