BiologicalActivity
PotentJAKinhibitor(IC50valuesare1,20,and112nMforJAK3,JAK2andJAK1respectively).Orallyactiveimmunosuppressant;exhibitsefficacyinrodentrheumatoidarthritismodels.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofCP690550(Tofacitinib)isreviewedonthechemicalprobeswebsite.
CompoundLibraries
CP690550citrateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 504.49 |
| Formula | C16H20N6O.C6H8O7 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 540737-29-9 |
| PubChemID | 10174505 |
| InChIKey | SYIKUFDOYJFGBQ-YLAFAASESA-N |
| Smiles | C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight504.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.98mL | 9.91mL | 19.82mL |
| 5mM | 0.4mL | 1.98mL | 3.96mL |
| 10mM | 0.2mL | 0.99mL | 1.98mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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ProductDatasheets
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