Biological Activity
Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 288.18 |
| Formula | C12H13N3O.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 879089-64-2 |
| PubChem ID | 46927988 |
| InChI Key | FLVJHUZZKVJQNH-UHFFFAOYSA-N |
| Smiles | Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.35 mL | 34.7 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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References
References are publications that support the products' biological activity.
Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241 PMID:
Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287
Keywords: CP 93129 dihydrochloride, supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience
