Biological Activity
Potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.
Compound Libraries
CP 94253 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 293.8 |
| Formula | C15H19N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 845861-39-4 |
| PubChem ID | 11652258 |
| InChI Key | PIIOXKQIZCVXMD-UHFFFAOYSA-N |
| Smiles | Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.38 | 100 | |
| ethanol | 7.34 | 25 | |
| water | 7.34 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 293.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.4 mL | 17.02 mL | 34.04 mL |
| 5 mM | 0.68 mL | 3.4 mL | 6.81 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.4 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fish et al (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146 391 PMID: 10550489
Knobelman et al (2000) Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors. J.Pharmacol.Exp.Ther. 292 1111 PMID: 10688630
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241 PMID:
Keywords: CP 94253 hydrochloride, supplier, Potent, selective, 5-HT1B, agonists, Serotonin, Receptors, CP94253, hydrochloride, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience
