BiologicalActivity
BETbromodomaininhibitor.DownregulatesMycexpression,causesG1cellcyclearrestandattenuatescellproliferationinhumanpancreaticneuroendocrinetumors.ArreststhegrowthofTcellacutelymphoblasticleukemiacellsinvitro(EC50=91.2nM).Alsoenhancestheantitumoreffectofrapamycin(Cat.No.1292)invitroandattenuatesrapamycininducedAktactivation.Orallybioavailable.
CompoundLibraries
CPI203isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 399.9 |
| Formula | C19H18ClN5OS |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1446144-04-2 |
| PubChemID | 71291068 |
| InChIKey | QECMENZMDBOLDR-AWEZNQCLSA-N |
| Smiles | NC(C[C@@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.99 | 100 | |
| ethanol | 4 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight399.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.5mL | 25.01mL |
| 5mM | 0.5mL | 2.5mL | 5mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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ProductDatasheets
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