Biological Activity
Positive allosteric modulator at mGlu1 and mGlu5; thought to act at a novel allosteric site. Potentiates mGlu5 responses by a mechanism distinct from that of VU 29 (Cat. No. 4458).
Technical Data
| M. Wt | 406.82 |
| Formula | C22H15ClN2O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 693288-97-0 |
| PubChem ID | 9931205 |
| InChI Key | UFOUABRZSDGGAZ-UHFFFAOYSA-N |
| Smiles | ClC1=CC(CN3C(C(C=CC=C4)=C4C3=O)=O)=C(NC(C2=CC=CC=C2O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.68 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 406.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.29 mL | 24.58 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
O'Brien et al (2004) A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J.Pharmacol.Exp.Ther. 309 568 PMID: 14747613
Chen et al (2008) N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 73 909 PMID: 18056795
Keywords: CPPHA, supplier, mglu, metabotropic, glutamate, receptors, pams, positive, allosteric, modulators, modulates, mglu1, mglu5, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
