Tocris/CRT 0066101/4975/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/CRT 0066101/4975/10/10 mg

Tocris/CRT 0066101/4975/10/10 mg

商品编号： 4975/10

品牌： Tocris Bioscience

市场价： ¥4900.00

美元价： 2940.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentproteinkinaseD(PKD)inhibitor

ChemicalName:2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenoldihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofproteinkinaseD(PKD);inhibitsallPKDisoforms(IC₅₀valuesare1,2and2.5nMforPKD1,PKD3andPKD2respectively).ExhibitsselectivityforPKDagainstapanelof>90proteinkinases,includingPKCα,MEK,ERK,c-Rafandc-Src.ReducesproliferationandcellviABIlityofpancreaticcancercellsexpressingmoderatelevelsofendogenousPKD1/2.Orallybioavailable.

TechnicalData

M.Wt	411.33
Formula	C₁₈H₂₂N₆O.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1883545-60-5
PubChemID	69074905
InChIKey	CXYCRYGNFKDPRH-FMOMHUKBSA-N
Smiles	OC1=C(C3=NC(NC[C@@H](CC)N)=CC=N3)C=C(C2=CN(C)N=C2)C=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	8.23	20
	water	41.13	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight411.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.43mL	12.16mL	24.31mL
5mM	0.49mL	2.43mL	4.86mL
10mM	0.24mL	1.22mL	2.43mL
50mM	0.05mL	0.24mL	0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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