Biological Activity
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.
Technical Data
| M. Wt | 247.29 |
| Formula | C14H17NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 215923-54-9 |
| PubChem ID | 2890 |
| InChI Key | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
| Smiles | O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 | |
| ethanol | 24.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 247.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Nagararjan et al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 41 650 PMID: 11640919
O'Neill et al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181 PMID: 15180479
Shimazaki et al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 575 94 PMID: 17727837
Huang et al (2016) Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 8 ra85 PMID: 27334260
Keywords: CX 546, supplier, AMPA, receptor, potentiator, Glutamate, Receptors, iGluR, Ionotropic, CX546, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
