BiologicalActivity
Selectivesphingosine-1-phosphatereceptor3(S1P3)allostericagonist(EC50=72-132nM).OccupiesadifferentspacewithintheligandbindingpocketofS1P3thanS1P.DisplaysnoactivityatS1P1,S1P2,S1P4andS1P5receptorsatconcentrationsupto10μM.Showsnosignificantactivitiesinaprofilingpanelof55GPCRs,ionchannelsandtransporters.
CompoundLibraries
CYM5541isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 316.44 |
| Formula | C19H28N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 945128-26-7 |
| PubChemID | 17253208 |
| InChIKey | NDKGACIWVAOUQH-UHFFFAOYSA-N |
| Smiles | O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 | |
| ethanol | 15.82 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.8mL | 31.6mL |
| 5mM | 0.63mL | 3.16mL | 6.32mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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ProductDatasheets
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