BiologicalActivity
SelectiveinhibitorofPI3-kinaseγ(IC50=1.0μMinaPI3-Kγ-dependentfMLP-inducedneutrophilmigrationassay).Exhibitslimitedoff-targeteffectsinkinomeprofilingof154identifiedlipidandproteinkinasesand922otherproteins.Orallyeffectiveinarodentmodelofinflammatorydisease.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
CZC24832isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 364.4 |
| Formula | C15H17FN6O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1159824-67-5 |
| PubChemID | 42623951 |
| InChIKey | RXRZPHQBTHQXSV-UHFFFAOYSA-N |
| Smiles | NC2=NN1C=C(C3=CN=CC(S(NC(C)(C)C)(=O)=O)=C3)C=C(F)C1=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight364.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.74mL | 13.72mL | 27.44mL |
| 5mM | 0.55mL | 2.74mL | 5.49mL |
| 10mM | 0.27mL | 1.37mL | 2.74mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |
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ProductDatasheets
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