BiologicalActivity
SelectiveD2-likedopaminereceptoragonist(Kivaluesare0.7,1.5,9.0and165nMforD2,D3,D4andD5receptorsrespectively)thatalsodisplayshighaffinityforseveralSEROtoninreceptorsubtypes(Ki=1.2-20.0nMfor5-HT1A,5-HT1D,5-HT2Aand5-HT2B).Inhibitssecretionofprolactinandgrowthhormoneandreverseslevodopa-induceddyskinesiasinParkinsonianmonkeys.
CompoundLibraries
CabergolineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 451.6 |
| Formula | C26H37N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 81409-90-7 |
| PubChemID | 90488776 |
| InChIKey | MNDMRWBGBXWMDE-YPAWHYETSA-N |
| Smiles | CC2=C(C(C[C@]3([H])[C@@]([H])2C[C@@H]([C@@](N(C(NCC)=O)CCCN(C)C)=O)CN3CC=C)=CN1)/C/1=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 4.51 | 10 | |
| DMSO | 45.16 | 100 | |
| ethanol | 45.16 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight451.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.21mL | 11.07mL | 22.14mL |
| 5mM | 0.44mL | 2.21mL | 4.43mL |
| 10mM | 0.22mL | 1.11mL | 2.21mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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ProductDatasheets
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