Biological Activity
Angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).
Compound Libraries
Candesartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 440.45 |
| Formula | C24H20N6O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 139481-59-7 |
| PubChem ID | 2541 |
| InChI Key | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
| Smiles | CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.45 | 100 | |
| ethanol | 0.44 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 440.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
Keywords: Candesartan, supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
