Biological Activity
Cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.
Technical Data
| M. Wt | 182.65 |
| Formula | C6H15ClN2O2 |
| Storage | Desiccate at RT |
| CAS Number | 51-83-2 |
| PubChem ID | 5831 |
| InChI Key | AIXAANGOTKPUOY-UHFFFAOYSA-N |
| Smiles | NC(OCC[N+](C)(C)C)=O.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.13 | 50 | |
| ethanol | 1.83 | 10 | |
| water | 18.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 182.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.47 mL | 27.37 mL | 54.75 mL |
| 5 mM | 1.09 mL | 5.47 mL | 10.95 mL |
| 10 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.09 mL |
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References
References are publications that support the products' biological activity.
Yan et al (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol.Pharmacol. 47 248 PMID: 7870032
Keywords: Carbamoylcholine chloride, supplier, Cholinergic, receptor, agonists, Muscarinic, Receptors, Acetylcholine, Nicotinic, Non-Selective, Subtypes, nAChR, Carbachol, Non-selective, Muscarinics, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
