Biological Activity
5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.
Technical Data
| M. Wt | 319.32 |
| Formula | C11H13N3O.C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 74885-72-6 |
| PubChem ID | 11709509 |
| InChI Key | PZQZSWAOVAMBQM-BTJKTKAUSA-N |
| Smiles | OC(=O)C=C/C(O)=O.NCCC1=CNC2=CC=C(C=C12)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 15.97 | 50 | |
| water | 31.93 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur.J.Pharmacol. 213 193 PMID: 1325915
Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206 PMID: 8401931
Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401 PMID: 1359584
Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046
Keywords: 5-Carboxamidotryptamine maleate, supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, AH-21467, 5-CT, Non-selective, 5-HT1, 5-HT7, Receptors, 5-ht5, Receptors, Non-selective, 5-HT1, Tocris Bioscience
