Biological Activity
A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.
Technical Data
| M. Wt | 315.38 |
| Formula | C14H16KN2O4 |
| Storage | Desiccate at -20°C |
| CAS Number | 148819-94-7 |
| PubChem ID | 2733502 |
| InChI Key | VYEUQMVIGXFZQU-UHFFFAOYSA-M |
| Smiles | [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 25 mM in ethanol and to 10 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 315.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.17 mL | 15.85 mL | 31.71 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.34 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.17 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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References
References are publications that support the products' biological activity.
Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387
Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578
Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579
Keywords: Carboxy-PTIO, potassium salt, supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, Nitric, Oxide, Other, Nitric, Oxide, Tocris Bioscience
