Biological Activity
Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Technical Data
| M. Wt | 410.94 |
| Formula | C24H26N2O2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 115092-85-8 |
| PubChem ID | 9822866 |
| InChI Key | LRJUHOBITQUXIO-UHFFFAOYSA-N |
| Smiles | Cl.OC(=O)C1=CC=C2NC=C(CCCCN3CCC(=CC3)C3=CC=CC=C3)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.09 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 410.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.17 mL | 24.33 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Haeusler et al (1992) Pharmacological basis for antihypertensive therapy with a novel dopamine agonist Eur.Heart J. 13 129 PMID: 1356783
Rump et al (1993) Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices. Eur.J.Clin.Pharmacol. 44 S47 PMID: 8097997
Hasse et al (1991) Neurochemical profile of EMD 45609 (carmoxirole), a dopamine DA2-receptor agonist. Naunyn-Schmied.Arch.Pharmacol. 343 588 PMID:
Keywords: Carmoxirole hydrochloride, supplier, Selective, peripherally, peripheral, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, EMD45609, EMD, 45609, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
