Biological Activity
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
Technical Data
| M. Wt | 2425.84 |
| Formula | C107H173N37O26S |
| Sequence | RSMRLSFRARGYGFRGPGLQL |
| Storage | Store at -20°C |
| CAS Number | 142211-96-9 |
| PubChem ID | 16143960 |
| InChI Key | HCEYIDADOJWYIM-DIWOTYQXSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2425.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 5 mM | 0.08 mL | 0.41 mL | 0.82 mL |
| 10 mM | 0.04 mL | 0.21 mL | 0.41 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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References
References are publications that support the products' biological activity.
Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623 PMID: 9294131
Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525 PMID: 11043569
Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29 PMID:
Keywords: Catestatin, supplier, Non-competitive, nicotinic, cholinergic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Chromogranin, A344-364, A344364, Chromogranin, A344-364, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
