BiologicalActivity
Selectivecyclooxygenase-2(COX-2)inhibitor(IC50valuesare15and0.04μMforCOX-1andCOX-2respectively).Anti-inflammatorywithshorterplasmahalf-lifeinvivothanSC58121(Cat.No.2895).Displayschemopreventiveactivityininvivotumormodels.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
CelecoxibisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 381.37 |
| Formula | C17H14F3N3O2S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 169590-42-5 |
| PubChemID | 2662 |
| InChIKey | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.53 | 25 | |
| ethanol | 19.07 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight381.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.62mL | 13.11mL | 26.22mL |
| 5mM | 0.52mL | 2.62mL | 5.24mL |
| 10mM | 0.26mL | 1.31mL | 2.62mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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ProductDatasheets
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