Biological Activity
High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
Licensing Information
Sold with the permission of the Ludwig Institute for Cancer Research Ltd
Technical Data
| M. Wt | 633.65 |
| Formula | C26H25F2N7O6S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1798871-30-3 |
| PubChem ID | 91801159 |
| InChI Key | HHJSKDRCUMVWKF-UHFFFAOYSA-N |
| Smiles | FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCOCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 63.37 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 633.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.58 mL | 7.89 mL | 15.78 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 10 mM | 0.16 mL | 0.79 mL | 1.58 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Wong et al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155 PMID: 25931445
Keywords: Centrinone, supplier, High, affinity, selective, PLK4, inhibitors, inhibits, centriole, centrosome, Polo-like, Kinase, Mitosis, Polo-like, Kinase, Tocris Bioscience
