Tocris/Centrinone B/5690/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Centrinone B/5690/10/10 mg

Tocris/Centrinone B/5690/10/10 mg

商品编号： 5690/10

品牌： Tocris Bioscience

市场价： ¥4580.00

美元价： 2748.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:HighaffinityandselectivePLK4inhibitor

AlternativeNames:LCR323

ChemicalName:2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectivePLK4inhibitor(K_i=0.6nM).Exhibits>2000-foldselectivityforPLK4overAuroraAandAuroraB.Depletescentrioleandcentrosomelevelsinvitro.Inducescellcyclearrestinnormalhumancelllinesinap53-dependentmanner.

LicensingInformation

SoldwiththepermissionoftheLudwigInstituteforCancerResearchLtd

TechnicalData

M.Wt	631.67
Formula	C₂₇H₂₇F₂N₇O₅S₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1798871-31-4
PubChemID	118704753
InChIKey	UPZNTUYHCRQOIQ-UHFFFAOYSA-N
Smiles	FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	31.58	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight631.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.58mL	7.92mL	15.83mL
5mM	0.32mL	1.58mL	3.17mL
10mM	0.16mL	0.79mL	1.58mL
50mM	0.03mL	0.16mL	0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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SolubilityData

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