Biological Activity
Anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABAA receptors.
Technical Data
| M. Wt | 273.73 |
| Formula | C11H12ClNO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 80-77-3 |
| PubChem ID | 2717 |
| InChI Key | WEQAYVWKMWHEJO-UHFFFAOYSA-N |
| Smiles | CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.37 | 100 | |
| ethanol | 6.84 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 273.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.27 mL | 36.53 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.31 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ervin and Cooper (1988) Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 245 137 PMID: 2896235
Simiand et al (1989) Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 297 272 PMID: 2567153
Merck Index 12 2155 PMID:
Keywords: Chlormezanone, supplier, Skeletal, muscle, relaxant, GABAA, Receptors, benzodiazepine, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
