Biological Activity
mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
Technical Data
| M. Wt | 300.22 |
| Formula | C14H8N2O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 606-59-7 |
| PubChem ID | 114918 |
| InChI Key | FSBKJYLVDRVPTK-UHFFFAOYSA-N |
| Smiles | O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 300.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.31 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print PMID: 22311707
Keywords: Cinnabarinic acid, supplier, metabotropic, glutamate, mglu4, agonists, selective, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
