Biological Activity
Selective α1 agonist. Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.
Compound Libraries
Cirazoline hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 252.74 |
| Formula | C13H16N2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 40600-13-3 |
| PubChem ID | 11957512 |
| InChI Key | XFRXWLWUUDJHPB-UHFFFAOYSA-N |
| Smiles | Cl.C(OC1=C(C=CC=C1)C1CC1)C1=NCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.27 | 100 | |
| water | 25.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.78 mL | 39.57 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.91 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Le Rouzic et al (1995) Binding of [3H]cirazoline to an imidazoline site in rat brain and kidney membranes. Eur.J.Pharmacol. 278 261 PMID: 7589165
Gellai and Ruffolo (1987) Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats. J.Pharmacol.Exp.Ther. 240 723 PMID: 2882013
Wikberg and Uklen (1990) Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J.Neurochem. 55 192 PMID: 1972387
Keywords: Cirazoline hydrochloride, supplier, Selective, α1, α1-adrenoceptor, alpha1-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, a1-adrenergic, agonists, Imidazoline, ligands, Receptors, General, Imidazolines, Adrenergic, Alpha-1, Receptors, General, Imidazolines, Adrenergic, Alpha-1, Receptors, Tocris Bioscience
