Biological Activity
Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).
Technical Data
| M. Wt | 206.59 |
| Formula | C6H7ClN2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 909400-43-7 |
| PubChem ID | 4694356 |
| InChI Key | FDSXCQTXUSQQFH-UHFFFAOYSA-N |
| Smiles | ClC1=C(CC(C(O)=O)N)ON=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 4.13 | 20 | |
| 1eq. NaOH | 20.66 | 100 | |
| water | 4.13 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 206.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.84 mL | 24.2 mL | 48.41 mL |
| 5 mM | 0.97 mL | 4.84 mL | 9.68 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bjerrum et al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246 PMID: 12747796
Kristensen et al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7 PMID:
Keywords: Cl-HIBO, supplier, Subtype-selective, AMPA, agonists, GluR1, GluR2, Glutamate, Receptors, iGluR, Ionotropic, Chloro-homoibotenic, acid, 4-Chlorohomoibotenic, acid, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
