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商品详细Tocris/Cladribine/5292/10/10 mg

Tocris/Cladribine/5292/10/10 mg

商品编号： 5292/10

品牌： Tocris Bioscience

市场价： ¥1900.00

美元价： 1140.00

产地：美国(厂家直采)

公司：

产品分类：细胞凋亡

公司分类： Apoptosis

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Deoxyadenosineanalog;pro-apoptotic

AlternativeNames:2-Chloro-2'-deoxyadenosine

ChemicalName:(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Adenosinedeaminase(ADA)-resistantanalogofdeoxyadenosine.Exhibitsanti-leukemicactivity;Inhibitscellgrowthoflymphoidandmyeloidneoplasm(IC₅₀=20-87nM).Pro-apoptotic;inducesDNAdouble-strandbreaks.Alsoinhibitsribonucleasereductase(IC₅₀=0.11-0.28μM).Displaysactivityinvitroandinvivo.Orallybioavailable.

TechnicalData

M.Wt	285.69
Formula	C₁₀H₁₂ClN₅O₃
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	4291-63-8
PubChemID	20279
InChIKey	PTOAARAWEBMLNO-KVQBGUIXSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	28.57	100
	water	1.43	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight285.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.5mL	17.5mL	35mL
5mM	0.7mL	3.5mL	7mL
10mM	0.35mL	1.75mL	3.5mL
50mM	0.07mL	0.35mL	0.7mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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