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商品详细Tocris/Clemizole hydrochloride/5371/50/50 mg

Tocris/Clemizole hydrochloride/5371/50/50 mg

商品编号： 5371/50

品牌： Tocris Bioscience

市场价： ¥7500.00

美元价： 4500.00

产地：美国(厂家直采)

公司：

产品分类：信号通路

公司分类： Signal_pathway

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:TRPC5blocker;alsoH₁antagoNIST

ChemicalName:1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazolehydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

TRPC5channelblocker(IC₅₀valuesare1.1,6.4,9.1,11.3and26.5μMforTRPC5,TRPC4,TRPC3,TRPC6andTRPC7respectively).ExhibitsminimaleffectonTRPM3,TRPM8andTRPV1-4channels.AlsohistamineH₁receptorantagonistandanticonvulsantinzebrafishDravetsyndromemodel.

CompoundLibraries

ClemizolehydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	362.3
Formula	C₁₉H₂₀ClN₃.HCl
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	1163-36-6
PubChemID	14412
InChIKey	DNFMJYXRIMLMBZ-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4CN2C(CN3CCCC3)=NC1=CC=CC=C12.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	18.11	50
	water	7.25	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight362.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.76mL	13.8mL	27.6mL
5mM	0.55mL	2.76mL	5.52mL
10mM	0.28mL	1.38mL	2.76mL
50mM	0.06mL	0.28mL	0.55mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ReconstitutionCalculator

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ProductDatasheets