Biological Activity
Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
Technical Data
| M. Wt | 266.56 |
| Formula | C9H9Cl2N3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 4205-91-8 |
| PubChem ID | 20179 |
| InChI Key | ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| Smiles | Cl[H].ClC1=CC=CC(Cl)=C1N=C1/NCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.99 | 75 | |
| water | 26.66 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 266.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.52 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.5 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Armitsu et al (1998) Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681 PMID: 9694921
Ernsberger et al (1987) Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1 PMID: 3030779
Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1 PMID: 7883019
Silva et al (1996) Dual effect of clonidine on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872 PMID: 8627569
Merck Index 12 2450 PMID:
Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949
Keywords: Clonidine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Adrenergic, Alpha-2, Receptors, I1, Receptors, Autophagy, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
