Biological Activity
Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
Technical Data
| M. Wt | 1721.03 |
| Formula | C81H113N19O19S2 |
| Sequence |
PCKNFFWKTFSSCK (Modifications: Disulfide bridge between 2 - 13) |
| Storage | Desiccate at -20°C |
| CAS Number | 193829-96-8 |
| PubChem ID | 16133803 |
| InChI Key | DDRPLNQJNRBRNY-WYYADCIBSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.70 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1721.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.58 mL | 2.91 mL | 5.81 mL |
| 5 mM | 0.12 mL | 0.58 mL | 1.16 mL |
| 10 mM | 0.06 mL | 0.29 mL | 0.58 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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References
References are publications that support the products' biological activity.
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1 PMID: 11227737
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID:
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228 PMID:
Keywords: Cortistatin 14, supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, Somatostatin, Receptors, Ghrelin, Receptors, Somatostatin, Receptors, Tocris Bioscience
