托克里斯/克唑替尼/4368/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细托克里斯/克唑替尼/4368/10/10毫克

托克里斯/克唑替尼/4368/10/10毫克

商品编号： 4368/10

品牌： Tocris Bioscience

市场价： ¥4900.00

美元价： 2940.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Potentc-MET/ALKinhibitor

AlternativeNames:PF02341066,PF2341066

ChemicalName:3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofc-METandanaplasticlymphomakinase(ALK)(cellIC₅₀valuesare8.0and20nMrespectively).Selectiveforc-METandALKagainst>120differentkinases.Displaysantitumorefficacyinmultipletumormodels;inhibitsc-MET-dependentproliferation,migrationandinvasionofhumantumorcellsinvitro.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	450.34
Formula	C₂₁H₂₂Cl₂FN₅O
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	877399-52-5
PubChemID	11626560
InChIKey	KTEIFNKAUNYNJU-GFCCVEGCSA-N
Smiles	ClC1=[C@@]([C@H](OC2=C(N)N=CC(C3=CN(C4CCNCC4)N=C3)=C2)C)C(Cl)=CC=C1F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	2eq.HCl	45.03	100
	DMSO	4.5	10
	ethanol	4.5	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight450.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.22mL	11.1mL	22.21mL
5mM	0.44mL	2.22mL	4.44mL
10mM	0.22mL	1.11mL	2.22mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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