Tocris/(<em>S</em>)-Crizotinib/6025/10/10 mg-免疫在线蚂蚁淘旗下平台

当前位置：首页 > 产品中心 > Other_enzymes > Tocris/(S)-Crizotinib/6025/10/10 mg

商品详细Tocris/(S)-Crizotinib/6025/10/10 mg

Tocris/(S)-Crizotinib/6025/10/10 mg

商品编号： 6025/10

品牌： Tocris Bioscience

市场价： ¥2900.00

美元价： 1740.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:MTH1inhibitor

ChemicalName:3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentMTH1inhibitor(IC₅₀=72nM).InducesDNAdamageanddisruptsnucleotidepoolhomeostasisincancercells.AlsoattenuatescolonyformationofKRAS-mutatedPANC1cellsinvitro.Suppressestumorgrowth~50%inacoloncancercarcinomaxenograftmodel.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc

TechnicalData

M.Wt	450.34
Formula	C₂₁H₂₂Cl₂FN₅O
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	1374356-45-2
PubChemID	56671814
InChIKey	KTEIFNKAUNYNJU-LBPRGKRZSA-N
Smiles	C[C@@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=CC(C3=CN(C4CCNCC4)N=C3)=CN=C2N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	9.01	20mMwithgentlewarming
	DMSO	22.52	50
	ethanol	9.01	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight450.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.22mL	11.1mL	22.21mL
5mM	0.44mL	2.22mL	4.44mL
10mM	0.22mL	1.11mL	2.22mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage:

BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets