BiologicalActivity
MajortanshinoneisolatedfromSalviamiltiorrhizathatexhibitsmultipleactivities.ExhibitsantitumoractivityviainhibitionSTAT3activity(IC50=4.6μM).Displaysantibacterialandanti-inflammatoryactivityandactsasanantidiabetesandantiobesityagentviaactivationofAMP-activatedproteinkinase(AMPK).AlsoimprovescognitiveimpairmentinAlzheimer'sdiseasetransgenicmicebyinhibitionofacetylcholinesterase(IC50=4.09μM)andreductioninAβpeptidegeneration.
TechnicalData
| M.Wt | 296.36 |
| Formula | C19H20O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 35825-57-1 |
| PubChemID | 160254 |
| InChIKey | GVKKJJOMQCNPGB-JTQLQIEISA-N |
| Smiles | O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.96 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight296.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.37mL | 16.87mL | 33.74mL |
| 5mM | 0.67mL | 3.37mL | 6.75mL |
| 10mM | 0.34mL | 1.69mL | 3.37mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
MolarityCalculator
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ProductDatasheets
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