Biological Activity
Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.
Technical Data
| M. Wt | 856.89 |
| Formula | C35H56N10O15 |
| Sequence |
ASTTTNYT (Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 106362-34-9 |
| PubChem ID | 184644 |
| InChI Key | AKWRNBWMGFUAMF-ZESMOPTKSA-N |
| Smiles | [H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 856.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.17 mL | 5.84 mL | 11.67 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.17 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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References
References are publications that support the products' biological activity.
Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51 PMID: 15043212
Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671 PMID: 15979806
Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83 PMID: 16002156
Keywords: DAPTA, supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral, Rantes, D-Ala-peptide, T-amide, Antivirals, Chemokine, CC, Receptors, Chemokine, CC, Receptors, Tocris Bioscience
