Biological Activity
p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.
Technical Data
| M. Wt | 468.42 |
| Formula | C21H22FN5S.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90489008 |
| InChI Key | ANQWETXPBPZVOF-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4C1=C(C2=CC=NC(NC5CC5)=N2)SC(C3CCNCC3)=N1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 46.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 468.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.35 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Kang et al (2010) DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 334 657 PMID: 20427474
Keywords: DBM 1285 dihydrochloride, supplier, DBM1285, dihydrochloride, P38, MAPK, inhibits, inhibitors, TNF-alpha, TNF-a, TNF-α, mitogen, activated, protein, kinase, 917811-28-0, p38, p38, Tocris Bioscience
