Biological Activity
Presynaptic depressant; highly potent agonist for group II mGlu receptors. Also available as part of the Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
Licensing Information
Sold with the permission of Suntory Ltd.
Technical Data
| M. Wt | 203.15 |
| Formula | C7H9NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 147782-19-2 |
| PubChem ID | 16758827 |
| InChI Key | MATPZHBYOVDBLI-FKNRSBSYSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@]1(C([H])(C(O)=O)C([H])1C(O)=O)[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 20.32 | 100 | |
| water | 20.32 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 203.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.92 mL | 24.61 mL | 49.22 mL |
| 5 mM | 0.98 mL | 4.92 mL | 9.84 mL |
| 10 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043 PMID: 9833633
Cartmell et al (1998) Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br.J.Pharmacol. 123 497 PMID: 9504391
Ishida et al (1993) A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord. Br.J.Pharmacol. 109 1169 PMID: 8401927
Ohfune et al (1993) Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues. Bioorg.Med.Chem.Lett. 3 15 PMID:
Keywords: DCG IV, supplier, potent, selective, group, II, agonist, NMDA, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, DCGIV, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
