Biological Activity
Systemically active anticonvulsant that is 30-100-fold more potent in vivo than the separate enantiomers (S)-3,4-DCPG (Cat. No. 1302) or (R)-3,4,-DCPG (Cat. No. 1395).
Technical Data
| M. Wt | 239.18 |
| Formula | C10H9NO6 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 176796-64-8 |
| PubChem ID | 3313698 |
| InChI Key | IJVMOGKBEVRBPP-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=CC=C(C(O)=O)C(=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 239.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.18 mL | 20.9 mL | 41.81 mL |
| 5 mM | 0.84 mL | 4.18 mL | 8.36 mL |
| 10 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902
Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991
Thomas et al (1998) Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Neuropharmacology 37 1223 PMID: 9849660
Keywords: (RS)-3,4-DCPG, supplier, Potent, systemically, active, anticonvulsant, Racemate, Glutamate, Ionotropic, Non-Selective, iGlur, Receptors, Group, III, mGluR8, mGlu8, Metabotropic, antagonists, Non-selective, Ionotropic, Glutamate, Glutamate, (Metabotropic), Group, III, Receptors, Non-selective, Ionotropic, Glutamate, Tocris Bioscience
