BiologicalActivity
Selectivediscoidindomainreceptor1(DDR1)tyrosinekinaseinhibitor(IC50valuesare105and413nMforDDR1andDDR2respectively).Inhibitsintegrin-inducedDDR1autophosphorylationinanosteosarcomacellline.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofDDR1-IN-1isreviewedonthechemicalprobeswebsite.
CompoundLibraries
DDR1-IN-1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 625.51 |
| Formula | C30H31F3N4O3.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| PubChemID | 90489006 |
| InChIKey | PBUOJKYQZINPKD-UHFFFAOYSA-N |
| Smiles | CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.28 | 50 | |
| water | 62.55 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight625.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.6mL | 7.99mL | 15.99mL |
| 5mM | 0.32mL | 1.6mL | 3.2mL |
| 10mM | 0.16mL | 0.8mL | 1.6mL |
| 50mM | 0.03mL | 0.16mL | 0.32mL |
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ProductDatasheets
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