BiologicalActivity
SelectiveinhibitorofAkt/PKB.InhibitsIGF-1-stimulatedphosphorylationandactivationofAkt(completeinhibitionat2.5μM),suppressingdownstreamactivationofmTOR,p70S6kinaseandS6ribosomalprotein.ShowsnoactivityatPDK1,SGK1orPI3-kinase.Inhibitscellgrowth(IC50~2-6μM)andinducesapoptosisinrhaBDomyosarcomacells.
CompoundLibraries
10-DEBChydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 381.34 |
| Formula | C20H25N2OCl.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 925681-41-0 |
| PubChemID | 16760284 |
| InChIKey | SVKSJUIYYCQZEC-UHFFFAOYSA-N |
| Smiles | Cl.CCN(CC)CCCCN1C2=CC=CC=C2OC2=C1C=C(Cl)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.13 | 100 | |
| water | 38.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight381.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.62mL | 13.11mL | 26.22mL |
| 5mM | 0.52mL | 2.62mL | 5.24mL |
| 10mM | 0.26mL | 1.31mL | 2.62mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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ProductDatasheets
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