Biological Activity
Selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D. (S)-3,5-DHPG (Cat. No. 0805) also available.
Technical Data
| M. Wt | 183.16 |
| Formula | C8H9NO4 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 19641-83-9 |
| PubChem ID | 108001 |
| InChI Key | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=CC(O)=CC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 1.83 | 10 | |
| 1eq. HCl | 18.32 | 100 | |
| 1eq. NaOH | 18.32 | 100 | |
| water | 1.83 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 183.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.46 mL | 27.3 mL | 54.6 mL |
| 5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 10 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ito et al (1992) 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors. NeuroReport 3 1013 PMID: 1362358
Mistry et al (1998) Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II-selective metabotropic glutamate receptor agonists. Br.J.Pharmacol. 123 581 PMID: 9504400
Pellegrini-Giampietro et al (1996) Pharmacological characterization of metabotropic glutamate recpetors coupled to phopholipase D in the rat hippocampus. Br.J.Pharmacol. 118 1035 PMID: 8799579
Palmer et al (1997) The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36 1517 PMID: 9517422
Keywords: (RS)-3,5-DHPG, supplier, Selective, group, I, mGlur, agonists, Group, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
