Biological Activity
An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
Technical Data
| M. Wt | 484.87 |
| Formula | C22H23Cl2N3OS.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 155512-52-0 |
| PubChem ID | 45073425 |
| InChI Key | BNWYENYHNOESCX-ZMBIFBSDSA-N |
| Smiles | ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.24 | 50 | |
| ethanol | 14.55 | 30 |
Preparing Stock Solutions
The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.31 mL | 20.62 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586
Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399
Keywords: DIPPA hydrochloride, supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
