Biological Activity
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
Compound Libraries
DMAB-anabaseine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 364.32 |
| Formula | C19H21N3.2HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 154149-38-9 |
| PubChem ID | 16759167 |
| InChI Key | DHCNEWWWKHBASC-YNHPUKFJSA-N |
| Smiles | CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.11 | 25 | |
| water | 36.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 364.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.45 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252 PMID: 7796104
Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967
Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320 PMID: 9600576
Keywords: DMAB-anabaseine dihydrochloride, supplier, Partial, agonists, α7, alpha7-containing, a7, receptors, antagonists, α4β2, a4b2, neuronal, nicotinic, Nicotinic, Receptors, Acetylcholine, nAChR, Nicotinic, (a7), Receptors, Nicotinic, (a4b2), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
