Biological Activity
Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
Technical Data
| M. Wt | 350.8 |
| Formula | C17H18N2O4.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1215833-62-7 |
| PubChem ID | 45261899 |
| InChI Key | FHCRBVQGMZUJKY-UHFFFAOYSA-N |
| Smiles | CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.54 | 50 | |
| water | 31.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.25 mL | 28.51 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396
Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441
Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180 PMID:
Keywords: DMCM hydrochloride, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
