BiologicalActivity
Selectiveinhibitorofthebonemorphogenicprotein(BMP)ALK2receptor(IC50=108nM).ExhibitsnodetectableinhibitionofAMPK,ALK5,KDR(VEGFR-2)orPDGFRβreceptors.BlocksBMP4-inducedphosphorylationofSmads1,5and8inHEK293cells.Promotesneurogenesisinhumaninducedpluripotentstemcells(iPSCs)whenusedincombinationwithSB431542(Cat.No.1614).
CompoundLibraries
DMH-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 380.44 |
| Formula | C24H20N4O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1206711-16-1 |
| PubChemID | 50997747 |
| InChIKey | JMIFGARJSWXZSH-UHFFFAOYSA-N |
| Smiles | CC(C)OC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=NC5=C4C=CC=C5)C=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.61 | 20 | |
| ethanol | 1.9 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight380.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.63mL | 13.14mL | 26.29mL |
| 5mM | 0.53mL | 2.63mL | 5.26mL |
| 10mM | 0.26mL | 1.31mL | 2.63mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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ProductDatasheets
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