Biological Activity
Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.
Technical Data
| M. Wt | 182.24 |
| Formula | C8H10N2OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 284028-90-6 |
| PubChem ID | 10219702 |
| InChI Key | HRYKZAKEAVZGJD-UHFFFAOYSA-N |
| Smiles | CC1=NC(=O)C2=C(N1)CCSC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.29 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 182.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.49 mL | 27.44 mL | 54.87 mL |
| 5 mM | 1.1 mL | 5.49 mL | 10.97 mL |
| 10 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.1 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472 PMID: 15466246
Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421 PMID: 15864271
Keywords: DR 2313, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase, Tocris Bioscience
