Tocris/（<em>R</em>）-DRF053二盐酸盐/3610/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/（R）-DRF053二盐酸盐/3610/50/50 mg

Tocris/（R）-DRF053二盐酸盐/3610/50/50 mg

商品编号： 3610/50

品牌： Tocris Bioscience

市场价： ¥19700.00

美元价： 11820.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:DualCK1/cdkinhibitor

ChemicalName:2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,ATP-competitiveinhibitorofcyclin-dependentkinase(cdk)andcaseinkinase1(CK1)(IC₅₀valuesare220,80and14nMforcdk1/cyclinB,cdk5/p25andCK1respectively).SelectiveoverGSK-3αβ(IC₅₀=4.1μM).Alsoshowntoinhibitamyloid-βproductioninN2A-APP₆₉₅cells.

CompoundLibraries

(R)-DRF053dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	490.43
Formula	C₂₃H₂₇N₇O.2HCl
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1241675-76-2
PubChemID	71433624
InChIKey	BQPRBNGSDBTKAK-ZEECNFPPSA-N
Smiles	CC(C)N2C1=NC(N[C@H](CC)CO)=NC(NC3=CC(C4=NC=CC=C4)=CC=C3)=C1N=C2.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	49.04	100
	water	49.04	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight490.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.04mL	10.2mL	20.39mL
5mM	0.41mL	2.04mL	4.08mL
10mM	0.2mL	1.02mL	2.04mL
50mM	0.04mL	0.2mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ReconstitutionCalculator

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ProductDatasheets