Biological Activity
Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.
Technical Data
| M. Wt | 313.06 |
| Formula | C11H15BrClN.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 40616-75-9 |
| PubChem ID | 38533 |
| InChI Key | NDDRNRRNYOULND-UHFFFAOYSA-N |
| Smiles | BrC1=CC=CC=C1CN(CC)CCCl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 31.31 | 100 | |
| water | 31.31 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 313.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.19 mL | 15.97 mL | 31.94 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.39 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.19 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771
Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495
Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79 PMID:
Keywords: DSP-4, supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Adrenergic, Related, Compounds, Adrenergic, Related, Compounds, Tocris Bioscience
