Biological Activity
Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
Technical Data
| M. Wt | 296.32 |
| Formula | C15H20O6 |
| Storage | Store at +4°C |
| CAS Number | 51481-10-8 |
| PubChem ID | 40024 |
| InChI Key | LINOMUASTDIRTM-QGRHZQQGSA-N |
| Smiles | CC1=C[C@]2([H])[C@]([C@@](C)(C[C@H]4O)[C@]3(CO3)[C@@]([H])4O2)(CO)[C@H](O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 8.89 | 30 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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References
References are publications that support the products' biological activity.
Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59 PMID: 18502741
Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247 PMID: 19336499
Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50 PMID: 20347963
Keywords: Deoxynivalenol, supplier, DON, vomitoxin, cytotoxic, mycotoxin, protein, synthesis, inhibitors, inhibits, 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, DON, Vomitoxin, Miscellaneous, Compounds, Miscellaneous, Compounds, Tocris Bioscience
