Biological Activity
Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.
Compound Libraries
Dexamethasone is also offered as part of the Tocriscreen Plus, Tocriscreen Library of FDA-Approved Compounds and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 392.47 |
| Formula | C22H29FO5 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50-02-2 |
| PubChem ID | 9830630 |
| InChI Key | UREBDLICKHMUKA-LSGPFJJXSA-N |
| Smiles | O=C1C=CC2(C)C(CC[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@@](O)4C(CO)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909 PMID: 10614771
Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45 PMID: 20648425
Teixeira et al (1996) Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317 PMID: 8735633
Merck Index 12 2986 PMID:
Laane et al (2009) Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018 PMID: 19390558
Keywords: Dexamethasone, supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, Glucocorticoid, Receptor, Autophagy, Mesenchymal, Stem, Cells, Glucocorticoid, Receptor, Tocris Bioscience
