Biological Activity
Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.
Technical Data
| M. Wt | 352.31 |
| Formula | C18H25NO.HBr |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 6700-34-1 |
| PubChem ID | 5464025 |
| InChI Key | MISZALMBODQYFT-URVXVIKDSA-N |
| Smiles | [H][C@@]12[C@@H]4CC(C=CC(OC)=C3)=C3[C@@](CCN4C)1CCCC2.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.09 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 352.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Choi et al (1987) Dextrorophan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on corticol neurons. J.Pharmacol.Exp.Ther. 242 713 PMID: 3039122
Keller et al (2008) Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. Eur.J.Neurosci. 27 874 PMID: 18279363
Keywords: Dextromethorphan hydrobromide, supplier, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
