Biological Activity
Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.
Technical Data
| M. Wt | 289.2 |
| Formula | C13H16N2O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 292634-27-6 |
| PubChem ID | 121513869 |
| InChI Key | WYIKBRGLNDJDEU-CQSOCPNPSA-N |
| Smiles | [H][C@]12[C@](CN3CC2)(CC3)CC4=NC=CC=C4O1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.78 | 20 | |
| water | 28.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 289.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.29 mL | 34.58 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.92 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614
Keywords: Dianicline, supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, Nicotinic, (a4b2), Receptors, Tocris Bioscience
