Biological Activity
Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
Compound Libraries
Diazoxide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 230.67 |
| Formula | C8H7ClN2O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 364-98-7 |
| PubChem ID | 3019 |
| InChI Key | GDLBFKVLRPITMI-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.07 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.34 mL | 21.68 mL | 43.35 mL |
| 5 mM | 0.87 mL | 4.34 mL | 8.67 mL |
| 10 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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References
References are publications that support the products' biological activity.
Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673
Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383
Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270
Merck Index 12 3051 PMID:
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